Biological processes critical to neuronal function that converge with endoplasmic reticulum proteins

Bacterial adhesins’ role in systemic infections & diseases

Drug discovery & development, peptide medicinal chemistry, opioid & anticancer peptides

Stem cell differentiation & engineering, cell material interactions, tissue engineering & regenerative medicine

Clinical translation of emerging diagnostics & amp; therapeutics for joint diseases

Regulation of sodium transport mechanisms in the aldosterone-sensitive distal nephron as they contribute to hypertension

Lifestyle based & alternative treatment modalities for addressing obesity & Type 2 Diabetes

Employing endogenously expressed cytokines to hinder retinal degeneration

Preventing or curing Type 1 Diabetes with gene therapy & amp; immunointerventions with self-antigens

Computational fluid dynamics, vascular adaptation, peripheral bypass graft & arteriovenous dialysis fistula

Epstein-Barr virus, B cell interaction models cancer development & progression

Network science, consumer health informatics, big data analytics, social media, security & privacy, software engineering

Role of acute kidney injury in outcomes of severe trauma & sepsis

Aging, memory, executive function, & plasticity

Regulation of Herpes Simplex virus latency & reactivation, & amp; novel therapies to treat HSV

Neurogenesis of cough; brainstem cough network configuration

Alzheimer’s Disease, Huntington’s Disease, ALS, neurodegeneration, & protein misfolding

Neuropsychology of emotion, basal ganglia & amp; limbic functions in emotion, TMS, psychophysiology, laterality, forensic europsychology

Chronic obstructive pulmonary disease & role of inflammation in Alpha-1 Antitrypsin deficiency

Antivirals & pharmacodynamics

Statistics in epidemiology, clinical trials, longitudinal data analysis, causal inference, & complex surveys

Developing therapies to prevent and/or cure Type 1 Diabetes

Time course modeling in pharmacokinetics & pharmacodynamics

Uncovering mechanisms of age-related impairment in hippocampal-dependent sensory discrimination

Weakening the virulence of disease-inducing oral bacteria through molecular mechanisms

Genetic therapies for cardiovascular disease, muscular dystrophies, & lysosomal storage disorders

Immune activation in elderly dementias, such as Alzheimer’s, Parkinson’s & tauopathies

Optimizing mobility in the neurologically impaired, including the elderly & individuals recovering from a stroke or spinal cord injury

Neuroimaging, age-associated cognitive & brain dysfunction, neurodegenerative disorders

Molecular control of external genital patterning in mammals

Relation of alcohol & drug use to risky behavior & STD infection

Epidemiology, addiction, community based research, interventions, health disparities, global health

Applying biostatistical approaches to autism & spinal cord injury

Microbial genetics & biofilms, inter-species (P. gingivalis & oral streptococci) & host-microbe interactions

Metabolic interactions between tumor cells and the immune system in GBM

Mathematical modeling & pharmacodynamics of anti-infective chemotherapy

Effect of aging on the myelopoietic response to trauma & sepsis

Role of circadian rhythms & the molecular clock mechanism in skeletal muscle homeostasis & health

Liquid biopsy for cancer prognosis and theragnosis; pathogen detection for public health

Application of genetic analysis to complex neurological disorders

Biomechanics & neural control of human locomotion, both in health & disability

Biomechanics & neural control of human locomotion, both in health & disability

Pathogenesis of head & neck cancers among racial & ethnic groups in the United States

Complex human microbial systems & their interactions with the host

Neuroplasticity, spinal cord injury, control of breathing, neurophysiology & respiratory physiology

Cellular mechanisms & molecular interactions involved in neurodegenerative diseases

Biologic, gene therapy based, & small molecule therapies for Alzheimer’s disease & other neurodegenerative diseases

Therapies to treat motor deficits following chronic spinal cord injury

Neural markers of movement disorders; deep brain stimulation; closed-loop neuromodulation

Mechanisms of normal & disordered airway protection

Gene replacement & stem cell therapies to treat lysosomal storage diseases

Nanomaterials engineered to direct immune responses for disease prophylaxis, implants, and immuno-therapies

Establishing mechanisms controlling host-bacteria interaction in the intestine during health & disease

Molecular signaling pathways leading to skeletal muscle atrophy caused by disuse, disease, sepsis & aging

Physiologic adaptations to pregnancy & effects of maternal physiology on fetal maturation & growth

Biomaterials & controlled release systems for vaccines, immuno-therapies & implants

Dopamine neuro-transmission regulation, pathogenesis of addiction, neurological & neuropsychiatric disorders

Central nervous system’s coordination of behavioral & physiological responses to stress

Biology of aging, free radicals, oxidative stress, & muscle atrophy

Virulence mechanisms of the Gram-positive pathogens

Generating constitutive & inducible model systems for the study of proteins & cellular pathways

Neurocognitive processes & sociocultural factors at the root of drug use & HIV/AIDS disparities

Symptom management in women with breast cancer

Reducing health disparities in alcohol use & alcohol-related consequences among minority children & adolescents

Cognitive aging & behavioral interventions strategies; statistical modeling

Mechanisms of fungal brain invasion & colonization; Host-pathogen interactions & immunology

Causes & neural underpinnings of OCD & anxiety spectrum disorders

Statistical analysis of genomic, proteomic & other “omic” data

Tracer based analysis of intermediary metabolism

Respiratory motor neuron plasticity, intermittent hypoxia, spinal injury, ALS, inflammation

Inflammation biology & the role of cytokines in burn, sepsis & wound healing

Pathogenesis in malaria, & its effects on the placenta

Molecular & functional characterization of genes affecting T cell effector functions & cellular mechanisms, B cell tolerance & functional differentiation

Software & data collection techniques to facilitate translational research in pediatric infectious disease

Addiction, aging, neurobehavior, neuro-physiology, sex differences, co-morbidities, & health disparities

Non-motor basal ganglia brain features & the cognitive, behavioral, & mood effects of deep brain stimulation

Neural engineering, device-tissue interfaces & neurostimulation

Mucosal immunology & vaccines

Epidemiology & prevention of atherosclerotic cardiovascular disease

Biomedical modelling & ‘big data’ mining focused on precision medicine & translational science

Human genetics, genetic mapping, positional cloning, transgenic models

Kaposi’s sarcoma-associated Herpesvirus (KSHV), the leading cause of AIDS-associated cancer

Testing the interactions of magnetic nanoparticles with cells & tissues

Defining the molecular pathways leading to neurodegeneration

Management of pain, experimental pain & psychophysics, rehabilitation, psychophysiology

Training the immune system to fight cancer with lipid nanoparticles

Cardiovascular disease in diabetics, patients with chronic kidney disease, systemic lupus erythematosus, & women with preeclampsia

Molecular mechanisms of aortic aneurysm pathogenesis

Interactions between stem cells & diseased/injured tissues, nanoparticle-based targeted drug/gene delivery systems & tissue engineering scaffolds

Reducing cancer-related health disparities for adults & children through implementation of evidence-based best practices for risk detection & treatment

Improving cancer patient care with experimental approaches & treatment strategies

Cognitive aging & dementia

Development of recombinant parvovirus vectors for human gene therapy

Biology & therapy for RNA processing disorders

Neuroinflammatory & immune system responses in gene-environment interactions leading to neurologic disease

Molecular mechanisms of tumorigenesis & chemoresistance in pancreatic cancer

Pancreatic BMS Cancer Biology (Medicine), tumor signaling & chemoresistance

How a complex cascade of injury & repair contributes to aortic aneurysms until inflammatory cells degrade the vessel walls

Pathophysiology of muscle atrophy & muscle regeneration, viral mediated gene therapy in muscle rehabilitation

Interface between vector-borne disease & land use

Analyses of intervention effects for Medicaid & VA cost, utilization, & outcomes in observational settings

Toxicity of chemicals & nanomaterials in aquatic ecosystems, genetic factors that influence iron status in mammals

Novel deep sequencing to study pathogenesis of myotonic dystrophy & develop therapeutics

Management of cancer pain & end-of-life issues

Novel cognitive & neuro-inflammation neuroimaging biomarkers & intervention approaches

Adaptive design of clinical trials & simultaneous statistical inference

Mechanisms of oncogenic transformation

Ischemia/reperfusion injury as a source of organ damage in transplantation, myocardial infarction, stroke, & peripheral vascular disease

Genetic epidemiology & statistical genetics for complex human diseases

Transcriptional regulation of intestinal immune responses